Capabilities part 1

  • Tuberculosis (TB) drug discovery: Drug target identification and validation using an integrated genetic, physiological and biochemical approach. This expertise is provided by the MRC/NHLS/UCT Molecular Mycobacteriology Research Unit (MMRU), which also serves as the UCT node of the Department of Science and Technology (DST)/National Research Foundation (NRF) Centre of Excellence for Biomedical TB Research. This laboratory, which was established at UCT in 2011, is located in the Institute of Infectious Disease and Molecular Medicine (IIDMM) and is run jointly by Professor Valerie Mizrahi (Director, IIDMM) and Dr Digby Warner. Research in the MMRU is focused on studying aspects of the physiology and metabolism of Mycobacterium tuberculosis of particular relevance to TB drug discovery and drug resistance. All research in the MMRU that involves the large-scale culturing and genetic manipulation of M. tuberculosis is carried out in a state-of-the-art BSL3 laboratory in the IIDMM which was refurbished in 2010 to accommodate the needs of the MMRU
  • Biochemistry: Recombinant protein expression, protein isolation and characterisation, protein-ligand binding using isothermal titration calorimetry, and development of enzyme assays for evaluating inhibitor efficacy
  • Computational Chemistry: ADME and permeability predictions, molecular modeling, virtual screening, chemoinformatics