Capabilities part 2

  • In vitro and in vivo DMPK (Drug Metabolism and Pharmacokinetics): in vitro ADME, in vivo PK evaluation in mice and rats
  • In vitro metabolite generation using mammalian systems (hepatocytes, microsomes, isolated CYP450s from mammalian cells), microbial systems/fungal/bacterial (whole cells, cell lysates, purified enzyme) and bio-engineered systems (bactosomes, bacterial CYP450s)
  • Metabolite identification and scale up by fermentation in bioreactor set ups
  • Development of assays for drugs in blood and serum by LC tandem MS, metabolite identification in serum using LC tandem MS
  • Haemozoin inhibition and haem binding measurements
  • Pharmacology of antimalarial drugs and malaria/HIV drug interactions
  • Medicinal Chemistry (Hit to Lead and Lead Optimization)
  • Parasitology: in vitro & in vivo antimalarial assays
  • Preparation and physicochemical characterization of polymorphs, solvates, co-crystals and cyclodextrin inclusion complexes of drug candidates
  • Structural Biology: structure-based drug discovery from determination of novel targets through to final structures – including the co-crystal structures of targets with hit/lead compounds